{"id":15924,"date":"2012-09-20T12:45:13","date_gmt":"2012-09-20T17:45:13","guid":{"rendered":"http:\/\/news.olemiss.edu\/?p=15924"},"modified":"2014-09-23T08:31:27","modified_gmt":"2014-09-23T13:31:27","slug":"clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults","status":"publish","type":"post","link":"https:\/\/web20.olemiss.edu\/news\/wordpress\/clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults\/","title":{"rendered":"Clinical Trial Reveals Pterostilbene Reduces Blood Pressure in Adults"},"content":{"rendered":"
\"\"<\/a>

Investigating pterostilbene at the University of Mississippi Medical Center are (from left) Michael E. Griswold, director of UMMC's Center for Biostatistics; Justin J. Sherman, associate professor of pharmacy practice; Krista D. Riche, clinical pharmacy specialist at St. Dominic Hospital; and Daniel M. Riche, assistant professor of pharmacy practice and medicine. UM photo by Jay Ferchaud.<\/p><\/div>\n

WASHINGTON, D.C. \u2013 A form of pterostilbene, a compound found naturally in blueberries, reduces blood pressure in adults, according to results of a clinical trial presented today at the American Heart Association\u2019s 2012 Scientific Sessions on High Blood Pressure Research in Washington, D.C.<\/p>\n

The randomized, double-blind, placebo-controlled study was conducted by University of Mississippi School of Pharmacy and School of Medicine researchers to determine whether pterostilbene (tero-STILL-bean), an ingredient being marketed as pTeroPure\u00ae<\/sup>, improves cardiovascular health.<\/p>\n

Investigators evaluated the ingredient in 80 patients with high cholesterol (total cholesterol of 200 or greater and\/or LDL cholesterol of 100 or greater). Twice daily for six to eight weeks, participants received either high (125 mg) doses of pterostilbene, low (50 mg) doses of pterostilbene, pterostilbene (50 mg) with grape extract (100 mg), or a placebo, said Daniel M. Riche, the study\u2019s principal investigator. Investigators assessed patients\u2019 blood pressure, body weight and blood lipids at the beginning and end of their participation in the study.<\/p>\n

\u201cWe found reduced systolic and diastolic blood pressure in patients who received the high dose of pterostilbene and reduced systolic blood pressure in patients who received the low dose of pterostilbene with grape extract,\u201d said Riche, an assistant professor of pharmacy practice and medicine at the UM Medical Center in Jackson.<\/p>\n

Participants in the high-dose pterostilbene group (250 mg per day) achieved significant reductions in blood pressure compared to placebo: 7.8 mmHg in systolic BP (p less than 0.01) and 7.3 mmHg in diastolic BP (p less than 0.001).<\/p>\n

The only change in lipids was an increase in LDL cholesterol with pterostilbene (24.9 mg\/dL, p less than 0.001), which was less among participants already on cholesterol-lowering medication and was not seen among those who also received the grape extract. Participants not on cholesterol medication also achieved a minor average reduction in body weight (reduced body mass index of\u00a0 0.59 kg\/m2<\/sup>) with pterostilbene; body weight did not change significantly compared to placebo for the other participants.<\/p>\n

Patent rights covering the use of pterostilbene for various health benefits were licensed from UM for commercial development two years ago by the ChromaDex Corp., which is marketing it as pTeroPure, the key ingredient in BluScience\u2122, a line of dietary supplements available in some 17,000 outlets across the country. The California-based company provided support to the university for its yearlong clinical study (http:\/\/clinicaltrials.gov identifier NCT 01267227).<\/p>\n

\u201cWe are pleased that the University of Mississippi Medical Center conducted our first human study, which was a key to us and our commitment to providing clinical proof for our ingredients,\u201d said Frank Jaksch Jr., CEO and co-founder of ChromaDex. \u201cThis is an important milestone for us in adding credibility to our products for further market expansion opportunities.\u201d<\/p>\n

Along with Dr. Marion Wofford, professor of medicine, the study\u2019s co-investigators include Justin J. Sherman, associate professor of pharmacy practice; Michael E. Griswold, director of UMMC\u2019s Center for Biostatistics; and Krista D. Riche, clinical pharmacy specialist at St. Dominic Hospital in Jackson.<\/p>\n

\u201cWe are pleased to work with ChromaDex to explore the potential of this dietary supplement ingredient to improve the health and well-being of people in the U.S. and around the globe,\u201d said School of Pharmacy Dean David D. Allen.<\/p>\n

ChromaDex is a leader in the development of phytochemical and botanical reference standards and the creation of associated intellectual property. The company is committed to sustainable \u201cgreen chemistry\u201d and provides dietary supplement, food, beverage, nutraceutical and cosmetic industries with novel ingredients, analytical tools and services to meet product regulatory, quality, efficacy and safety standards. For more information about the company, visit http:\/\/chromadex.com<\/a>.<\/p>\n

The UM School of Pharmacy has earned national and international recognition for accomplishments in education; basic, translational and clinical research; and professional community service. Its faculty members are involved in patient care and research at the university\u2019s hospitals and clinics and are dedicated to improving health through practice, teaching and research. For more information about the school, visit http:\/\/www.pharmacy.olemiss.edu<\/a>.<\/p>\n

The UM Medical Center is the university\u2019s academic health sciences campus. UMMC operates five hospitals, five schools and the state\u2019s largest biomedical and health science research enterprise. The Medical Center\u2019s threefold mission is to educate tomorrow\u2019s health care professionals, conduct innovative research to improve human health and to provide the highest quality care available to the state\u2019s population. For more information about programs at the Medical Center, go to http:\/\/www.umc.edu\/<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

WASHINGTON, D.C. \u2013 A form of pterostilbene, a compound found naturally in blueberries, reduces blood pressure in adults, according to results of a clinical trial presented today at the American Heart Association\u2019s 2012 Scientific Sessions on High Blood Pressure Research in Washington, D.C. The randomized, double-blind, placebo-controlled study was conducted by University of Mississippi SchoolRead the story …<\/a><\/p>\n","protected":false},"author":1,"featured_media":15925,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[4,209,199,126,473],"tags":[935],"yoast_head":"\nClinical Trial Reveals Pterostilbene Reduces Blood Pressure in Adults - Ole Miss News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/news.olemiss.edu\/clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical Trial Reveals Pterostilbene Reduces Blood Pressure in Adults - Ole Miss News\" \/>\n<meta property=\"og:description\" content=\"WASHINGTON, D.C. \u2013 A form of pterostilbene, a compound found naturally in blueberries, reduces blood pressure in adults, according to results of a clinical trial presented today at the American Heart Association\u2019s 2012 Scientific Sessions on High Blood Pressure Research in Washington, D.C. The randomized, double-blind, placebo-controlled study was conducted by University of Mississippi SchoolRead the story …\" \/>\n<meta property=\"og:url\" content=\"http:\/\/news.olemiss.edu\/clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults\/\" \/>\n<meta property=\"og:site_name\" content=\"Ole Miss News\" \/>\n<meta property=\"article:published_time\" content=\"-0001-11-30T00:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2014-09-23T13:31:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-content\/uploads\/2012\/09\/Pterostilbene.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2048\" \/>\n\t<meta property=\"og:image:height\" content=\"1150\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@OleMissRebels\" \/>\n<meta name=\"twitter:site\" content=\"@OleMissRebels\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/web20.olemiss.edu\/news\/wordpress\/#website\",\"url\":\"https:\/\/web20.olemiss.edu\/news\/wordpress\/\",\"name\":\"Ole Miss News\",\"description\":\"The official source for University of Mississippi news\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":\"https:\/\/web20.olemiss.edu\/news\/wordpress\/?s={search_term_string}\",\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"@id\":\"http:\/\/news.olemiss.edu\/clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults\/#primaryimage\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-content\/uploads\/2012\/09\/Pterostilbene.jpg\",\"width\":\"2048\",\"height\":\"1150\",\"caption\":\"Investigating pterostilbene at the University of Mississippi Medical Center are (from left) Michael E. Griswold, director of UMMC's Center for Biostatistics; Justin J. Sherman, associate professor of pharmacy practice; Krista D. Riche, clinical pharmacy specialist at St. Dominic Hospital; and Daniel M. Riche, assistant professor of pharmacy practice and medicine. UM photo by Jay Ferchaud.\"},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/news.olemiss.edu\/clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults\/#webpage\",\"url\":\"http:\/\/news.olemiss.edu\/clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults\/\",\"name\":\"Clinical Trial Reveals Pterostilbene Reduces Blood Pressure in Adults - Ole Miss News\",\"isPartOf\":{\"@id\":\"https:\/\/web20.olemiss.edu\/news\/wordpress\/#website\"},\"primaryImageOfPage\":{\"@id\":\"http:\/\/news.olemiss.edu\/clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults\/#primaryimage\"},\"datePublished\":\"-0001-11-30T00:00:00+00:00\",\"dateModified\":\"2014-09-23T13:31:27+00:00\",\"author\":{\"@id\":\"https:\/\/web20.olemiss.edu\/news\/wordpress\/#\/schema\/person\/4515cb1b4f8a759552c0827c3df56430\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/news.olemiss.edu\/clinical-trial-reveals-pterostilbene-reduces-blood-pressure-in-adults\/\"]}]},{\"@type\":\"Person\",\"@id\":\"https:\/\/web20.olemiss.edu\/news\/wordpress\/#\/schema\/person\/4515cb1b4f8a759552c0827c3df56430\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/web20.olemiss.edu\/news\/wordpress\/#personlogo\",\"inLanguage\":\"en-US\",\"url\":\"http:\/\/0.gravatar.com\/avatar\/3e8e7562bf6d779d771ad8ce4cecd7ef?s=96&d=mm&r=g\",\"caption\":\"admin\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","_links":{"self":[{"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/posts\/15924"}],"collection":[{"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/comments?post=15924"}],"version-history":[{"count":2,"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/posts\/15924\/revisions"}],"predecessor-version":[{"id":15926,"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/posts\/15924\/revisions\/15926"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/media\/15925"}],"wp:attachment":[{"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/media?parent=15924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/categories?post=15924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web20.olemiss.edu\/news\/wordpress\/wp-json\/wp\/v2\/tags?post=15924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}